{"id":210,"date":"2022-10-25T18:58:37","date_gmt":"2022-10-25T16:58:37","guid":{"rendered":"https:\/\/supra-mars.univ-amu.fr\/?page_id=210"},"modified":"2022-12-09T11:52:28","modified_gmt":"2022-12-09T09:52:28","slug":"cucurbiturils","status":"publish","type":"page","link":"https:\/\/supra-mars.univ-amu.fr\/?page_id=210","title":{"rendered":"Cucurbiturils"},"content":{"rendered":"\n

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Cucurbiturils<\/h2>\n\n\n\n

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Cucurbiturils are a remarkable class of host compounds often featured by very high binding constants enabling them to form stable inclusion complexes with a myriad of molecules in water. Their shape resembling that of gourds or pumpkins inspired their name given after their discovery in 1981. Today, more and more research groups worldwide work on these fascinating macrocycles. These non-toxic macrocycles are able to encapsulate many drugs thereby improving key properties of medicines like solubility or therapeutic efficacy, but they are also used to capture unpleasant odorant molecules or inversely release fragrances. They are also used to capture gases and to build biological assays, imaging agents, dynamic supramolecular polymers, smart crystals or hybrid materials.<\/p>\n\n\n\n

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More specifically, here follows our research topics (Anthony Kermagoret, David Bardelang):<\/u><\/strong><\/p>\n\n\n\n

1- Artificial molecular switches and machines in water<\/strong><\/strong><\/p>\n\n\n\n

Since 2015 we have been working on stimuli-reponsive host-guest complexes featuring cucurbiturils. We found that pH-responsive viologens carrying an imidazole function allow for tuning the ring position along a molecular track thanks to pH or silver cations. In parallel, we developed a system enabling guest exchange in the cavity of CB[7] according to a partial energy ratchet mechanism.<\/p>\n\n\n\n

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